Normal & neoplastic stem cell (ML15)

Normal and Neoplastic Stem Cells

A stem cell is broadly defined as a cell that retains the capacity to self-renew, a feature that confers the ability to continuously make identical daughter cells or additional cells that will differentiate into downstream progeny. This highly regulated genetic program to retain "stemness" is under active investigation. Research in our laboratory has explored similarities and differences in emb...

Quantification of Crypt and Stem Cell Evolution in the Normal and Neoplastic Human Colon

Human intestinal stem cell and crypt dynamics remain poorly characterized because transgenic lineage-tracing methods are impractical in humans. Here, we have circumvented this problem by quantitatively using somatic mtDNA mutations to trace clonal lineages. By analyzing clonal imprints on the walls of colonic crypts, we show that human intestinal stem cells conform to one-dimensional neutral dr...

Cancer Stem Cell-Related Markers in Normal and Neoplastic Oral Mucosa

Normal and Neoplastic Hematopoiesis

specifically. The book is supported by over 200 references and half again as many personal communications. The high-quality scanning electron micrographs of pollen grains are especially appealing. Willow, mimosa, and dandelion pollen have an architecture as intricate and beautiful as the plant superstructure which supports them. The spiny spherical pollen grains of ambrosia (ragweed) make them ...

Stem cell in gastrointestinal structure and neoplastic development.

Correspondence to: M Brittan, Histopathology Unit, Cancer Research UK, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK; [email protected] _________________________ S tem cells are primitive cells located in a specialised mesenchymal ‘‘niche’’ that lack expression of any definitive markers of lineage commitment and are therefore difficult to define and identify. Stem cells maintain their ...